Il15ra^tm2.1Ama
Targeted Allele Detail

Summary

• Symbol: Il15ra^tm2.1Ama
• Name: interleukin 15 receptor, alpha chain; targeted mutation 2.1, Averil Ma
• MGI ID: MGI:4417841
• Synonyms: Il15ra^fl
• Gene: Il15ra Location: Chr2:11710101-11739128 bp, + strand Genetic Position: Chr2, 8.97 cM
• Alliance: Il15ra^tm2.1Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155298
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites flanking exons 2 and 3 as well as an FRT flanked neomycin expression cassette were inserted by homologous recombination. The neomycin resistance cassette was then removed by flp mediated recombination. (J:155298)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il15ra Mutation: 39 strains or lines available

References

• Original: J:155298 Mortier E, et al., Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity. 2009 Nov 20;31(5):811-22
• All: 9 reference(s)