Acsl1^tm1Rcol
Targeted Allele Detail

Summary

• Symbol: Acsl1^tm1Rcol
• Name: acyl-CoA synthetase long-chain family member 1; targeted mutation 1, Rosalind Coleman
• MGI ID: MGI:4417846
• Synonyms: Acsl1^flox
• Gene: Acsl1 Location: Chr8:46924214-46989088 bp, + strand Genetic Position: Chr8, 26.36 cM, cytoband B2
• Alliance: Acsl1^tm1Rcol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155714
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site and FRT flanked MC1-neo cassette were inserted 5' to exon 2 and an additional loxP site was placed immediately 3' of exon 2. The neomycin cassette was then excised by transient expression of Flpe recombinase. Cre expression in the liver of homozygous mice eliminates most mRNA for this gene. (J:155714)

Generation of Acsl1^tm1Rcol allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acsl1 Mutation: 37 strains or lines available

References

• Original: J:155714 Li LO, et al., Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. J Biol Chem. 2009 Oct 9;284(41):27816-26
• All: 19 reference(s)