Gata5^tm1Eem
Targeted Allele Detail

Summary

• Symbol: Gata5^tm1Eem
• Name: GATA binding protein 5; targeted mutation 1, Edward E Morrisey
• MGI ID: MGI:4417873
• Synonyms: Gata5^tm2Eem
• Gene: Gata5 Location: Chr2:179966926-179976492 bp, - strand Genetic Position: Chr2, 102.85 cM
• Alliance: Gata5^tm1Eem page

Ventriclular abnormalities in Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/Gata5^tm1Eem and Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/Gata5⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155855
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: This mutant allele retains the 5' region of the gene through the first 20 base pairs of exon 2, which encode the first zinc finger of the protein. A lacZ-PGK-neo cassette has replaced the remaining 3' portion of exon2 and all of intron 2 and exon3, including the second and third zinc finger coding sequences. Neither RT-qPCR analysis nor in situ hybridization to E10.5 embryos detected any transcripts. (J:155855)

Generation of the Gata5^tm1Eem allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata5 Mutation: 17 strains or lines available

References

• Original: J:155855 Singh MK, et al., Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice. J Biol Chem. 2010 Jan 15;285(3):1765-72
• All: 2 reference(s)