Tg(ACTA1-Il15)10941Lsq
Transgene Detail

Summary

• Symbol: Tg(ACTA1-Il15)10941Lsq
• Name: transgene insertion 10941, LeBris Smith Quinn
• MGI ID: MGI:4417893
• Synonyms: HSA-natLSP-IL15
• Transgene: Tg(ACTA1-Il15)10941Lsq Location: unknown
• Alliance: Tg(ACTA1-Il15)10941Lsq page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-Il15)10941Lsq expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il15 (MGI:103014)

• Mutation details: The HSA-natLSP-IL15 transgene was designed with a modified human skeletal actin (HSA or ACTA1) promoter fragment (bases -2139 to +239), murine long signal peptide (LSP) isoform interleukin-15 (Il15) cDNA, and polyA signal. This transgene was microinjected into C57BL/6 x C3H hybrid oocyte pronuclei. Founder mice were identified and bred with C57BL/6J mice to establish line 10941 (with a stable single transgene insertion point). IL-15 mRNA/protein expression in skeletal muscle is approximately 300-fold/400-fold greater in hemizygous males and approximately 100-fold/400-fold greater in hemizygous females, respectively. (J:145611)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(ACTA1-Il15)10941Lsq/0	involves: C3H * C57BL/6

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
adipose tissue	N
adipose tissue phenotype	N
growth/size/body	N
growth/size/body region phenotype	N
hematopoietic system	N
hematopoietic system phenotype	N
homeostasis/metabolism	√
homeostasis/metabolism phenotype	N
abnormal interleukin level	√
immune system	√
abnormal interleukin level	√
skeleton	N
skeleton phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:145611 Quinn LS, et al., Oversecretion of interleukin-15 from skeletal muscle reduces adiposity. Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E191-202
• All: 2 reference(s)