Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
Transgene Detail
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Symbol: |
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte |
Name: |
transgene insertion 10, TaconicArtemis |
MGI ID: |
MGI:4417910 |
Synonyms: |
ARTE10, Tg(Thy1-PSEN1*M146V/Thy1-APP*swe)10Arte |
Transgene: |
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte Location: unknown
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Alliance: |
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte page
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Onset and development of plaques in Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mice
Show the 2 phenotype image(s) involving this allele.
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte expresses
2 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
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The gene encodes for the Swedish mutations. |
human |
PSEN1 (5663) |
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Mutation details: This transgene is composed of two constructs containing the Thy1 promoter driving expression of human PSEN1 with the amino acid substitution of valine for methionine at position 146 and human APP with the Swedish familial Alzheimer disease mutation (K670N, M671L). Line 10 (also known as 10-279) was selected as the representative line.
(J:155410)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:155410 Willuweit A, et al., Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS One. 2009;4(11):e7931 |
All: |
5 reference(s) |
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