Tg(KRT14-Fyn*)aJsey
Transgene Detail

Summary

• Symbol: Tg(KRT14-Fyn*)aJsey
• Name: transgene insertion a, John Seykora
• MGI ID: MGI:4417930
• Synonyms: K14-Fyn Y528F, Tg(Krt14-Fyn*)1Jsey
• Transgene: Tg(KRT14-Fyn*)aJsey Location: unknown
• Alliance: Tg(KRT14-Fyn*)aJsey page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Fyn*)aJsey expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fyn (MGI:95602)

• Mutation details: Murine FynY528F cDNA was inserted downstream of the human keratin 14 promoter. Two independent lines with hyperkeratotic plaques and tumor phenotype were derived. Line a was generated. (J:155536)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:155536 Zhao L, et al., Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53. Cancer Res. 2009 Dec 15;69(24):9439-47
• All: 1 reference(s)