Slitrk6^tm1.1Jaru
Targeted Allele Detail

Summary

• Symbol: Slitrk6^tm1.1Jaru
• Name: SLIT and NTRK-like family, member 6; targeted mutation 1.1, Jun Aruga
• MGI ID: MGI:4417931
• Gene: Slitrk6 Location: Chr14:110986012-110992581 bp, - strand Genetic Position: Chr14, 57.2 cM, cytoband E3
• Alliance: Slitrk6^tm1.1Jaru page

Cochlear innervation defects in Slitrk6^tm1.1Jaru/Slitrk6^tm1.1Jaru mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155405
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The entire 3.3 kb open-reading frame was replaced with a floxed neo cassette. The neo cassette was subsequently excised by cre mediated recombination. Transcript absence was confirmed by RT-PCR. (J:155405)

Generation of the Slitrk6^tm1.1Jaru allele

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slitrk6 Mutation: 55 strains or lines available

References

• Original: J:155405 Katayama K, et al., Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice. PLoS One. 2009;4(11):e7786
• All: 3 reference(s)