Rif1^tm1.1Sbcb
Targeted Allele Detail

Summary

• Symbol: Rif1^tm1.1Sbcb
• Name: replication timing regulatory factor 1; targeted mutation 1.1, Sara B C Buonomo
• MGI ID: MGI:4417933
• Synonyms: Rif1^F
• Gene: Rif1 Location: Chr2:51962844-52012395 bp, + strand Genetic Position: Chr2, 29.98 cM
• Alliance: Rif1^tm1.1Sbcb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155449
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 5 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Flp mediated recombination removed the neo cassette leaving exons 5 through 7 floxed. (J:155449)

Generation of the Rif1^tm1.1Sbcb allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rif1 Mutation: 172 strains or lines available

References

• Original: J:155449 Buonomo SB, et al., Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol. 2009 Nov 2;187(3):385-98
• All: 9 reference(s)