Pdc^tm1Luhe
Targeted Allele Detail

Summary

• Symbol: Pdc^tm1Luhe
• Name: phosducin; targeted mutation 1, Lutz Hein
• MGI ID: MGI:4417957
• Gene: Pdc Location: Chr1:150195168-150209657 bp, + strand Genetic Position: Chr1, 63.84 cM
• Alliance: Pdc^tm1Luhe page

Increased pupil diameter in Pdc^tm1Luhe/Pdc^tm1Luhe mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155373
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on retinal extracts. (J:155373)

Generation of the Pdc^tm1Luhe allele

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdc Mutation: 22 strains or lines available

References

• Original: J:155373 Beetz N, et al., Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest. 2009 Dec;119(12):3597-3612
• All: 1 reference(s)