Tg(tetO-HDAC5*)1Eno
Transgene Detail

Summary

• Symbol: Tg(tetO-HDAC5*)1Eno
• Name: transgene insertion 1, Eric N Olson
• MGI ID: MGI:4417969
• Synonyms: HDAC5(S/A)
• Transgene: Tg(tetO-HDAC5*)1Eno Location: unknown
• Alliance: Tg(tetO-HDAC5*)1Eno page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: This transgene consists of a FLAG-tagged version of human HDAC5 expressed from a tetracycline responsive promoter. In addition serine-to-alanine mutations, at residues 259 and 498, were created to prevent the export of the protein to the cytosol. This transgene acts as a dominant-negative regulator of myocyte enhancer factor-2 signaling. (J:81967)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:81967 Czubryt MP, et al., Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1711-6
• All: 2 reference(s)