Gata3^tm2Jeng
Targeted Allele Detail

Summary

• Symbol: Gata3^tm2Jeng
• Name: GATA binding protein 3; targeted mutation 2, James Douglas Engel
• MGI ID: MGI:4418042
• Synonyms: Gata3^g
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm2Jeng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155686
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A floxed mouse Gata3/EGFP fusion cDNA was inserted into exon 2. This is a hypomorphic allele. The abundance of fusion protein resulting from this allele is only about 8% that of protein resulting from the unmodified allele. (J:155686)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 32 strains or lines available

References

• Original: J:155686 Hosoya T, et al., GATA-3 is required for early T lineage progenitor development. J Exp Med. 2009 Dec 21;206(13):2987-3000
• All: 6 reference(s)