Hdac4^tm2.1Eno
Targeted Allele Detail

Summary

• Symbol: Hdac4^tm2.1Eno
• Name: histone deacetylase 4; targeted mutation 1, Eric N Olson
• MGI ID: MGI:4418117
• Synonyms: HDAC4^lox
• Gene: Hdac4 Location: Chr1:91856501-92123421 bp, - strand Genetic Position: Chr1, 46.24 cM
• Alliance: Hdac4^tm2.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127416
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was floxed resulting in an out-of-frame mutation in the Hdac4 allele. The neo cassette has been removed. (J:127416)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac4 Mutation: 112 strains or lines available

References

• Original: J:127416 Potthoff MJ, et al., Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007 Sep;117(9):2459-67
• All: 31 reference(s)