Aqp12^tm1Rai
Targeted Allele Detail

Summary

• Symbol: Aqp12^tm1Rai
• Name: aquaporin 12; targeted mutation 1, Tatemitsu Rai
• MGI ID: MGI:4418194
• Synonyms: Aqp12^tm1Suc
• Gene: Aqp12 Location: Chr1:92934056-92939991 bp, + strand Genetic Position: Chr1, 46.72 cM
• Alliance: Aqp12^tm1Rai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155920
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a 1.8 kb neomycin cassette. Both Northern blot analysis an RT-PCR demonstrate the absence of transcript. (J:155920)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp12 Mutation: 20 strains or lines available

References

• Original: J:155920 Ohta E, et al., Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1368-78
• All: 1 reference(s)