Sdhd^tm1Jpb
Targeted Allele Detail

Summary

• Symbol: Sdhd^tm1Jpb
• Name: succinate dehydrogenase complex, subunit D, integral membrane protein; targeted mutation 1, Jean-Pierre Bayley
• MGI ID: MGI:4418212
• Gene: Sdhd Location: Chr9:50507657-50515112 bp, - strand Genetic Position: Chr9, 27.75 cM, cytoband B
• Alliance: Sdhd^tm1Jpb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155380
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: An IRES-LacZ Neo cassette replaced exon 3 by homologous recombination. Quantitative RT-PCR analysis indicated a 50% reduction in expression in multiple tissues from heterozygous mice. (J:155380)

Generation of Sdhd^tm1Jpb allele

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Sdhd^tm1Jpb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sdhd Mutation: 16 strains or lines available

References

• Original: J:155380 Bayley JP, et al., Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma. PLoS One. 2009;4(11):e7987
• All: 2 reference(s)