Lfng^tm1.2Egan
Targeted Allele Detail

Summary

• Symbol: Lfng^tm1.2Egan
• Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1.2, Sean E Egan
• MGI ID: MGI:4418228
• Synonyms: Lfng^delta2
• Gene: Lfng Location: Chr5:140593096-140601300 bp, + strand Genetic Position: Chr5, 79.15 cM
• Alliance: Lfng^tm1.2Egan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155893
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exon 2. Deletion of exon 2 is predicted to cause a frame shift that destabilizes the resulting transcript. RT-PCR confirmed the absence of endogenous transcript and reduced expression of a truncated one. (J:155893)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lfng^tm1.2Egan

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lfng Mutation: 32 strains or lines available

References

• Original: J:155893 Xu K, et al., Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L45-56
• All: 3 reference(s)