Adam8^tm1.1Mdz
Targeted Allele Detail

Summary

• Symbol: Adam8^tm1.1Mdz
• Name: a disintegrin and metallopeptidase domain 8; targeted mutation 1.1, Marc D Zack
• MGI ID: MGI:4418309
• Synonyms: ADAM8^E330Q, ADAM8EQ
• Gene: Adam8 Location: Chr7:139558845-139572475 bp, - strand Genetic Position: Chr7, 84.96 cM, cytoband F3-F5
• Alliance: Adam8^tm1.1Mdz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155243
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A glutamic acid at residue 330 was mutated to a glutamine by a point mutation in exon 11. The targeting vector contained a loxP-flanked neomycin cassette, that was removed by cre-mediated recombination. An activity assay confirmed the absence of ADAM8 peptidase activity in cells from homozygous mice. (J:155243)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam8 Mutation: 45 strains or lines available

References

• Original: J:155243 Zack MD, et al., Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8). Clin Exp Immunol. 2009 Nov;158(2):246-56
• All: 2 reference(s)