Atoh1^tm4.1Hzo
Targeted Allele Detail

Summary

• Symbol: Atoh1^tm4.1Hzo
• Name: atonal bHLH transcription factor 1; targeted mutation 4.1, Huda Y Zoghbi
• MGI ID: MGI:4418332
• Synonyms: Atoh1-EGFP, Atoh1^EGFP, Math1^m1GFP
• Gene: Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
• Alliance: Atoh1^tm4.1Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155760
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP sequence was fused to the 3' end of the coding sequence and was followed by an frt flanked PGK-neomycin selection cassette. The selection cassette was subsequently excised by crossing to mice carrying Gt(ROSA)26Sor^tm1(FLP1)Dym. (J:155760)

Expression

In Mice Carrying this Mutation:

30 assay results 5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atoh1 Mutation: 37 strains or lines available

References

• Original: J:155760 Rose MF, et al., Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron. 2009 Nov 12;64(3):341-54
• All: 47 reference(s)