Kcnh3^tm1Akmi
Targeted Allele Detail

Summary

• Symbol: Kcnh3^tm1Akmi
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 3; targeted mutation 1, Akira Miyake
• MGI ID: MGI:4418359
• Synonyms: BEC1 KO
• Gene: Kcnh3 Location: Chr15:99122742-99140698 bp, + strand Genetic Position: Chr15, 56.08 cM, cytoband F3
• Alliance: Kcnh3^tm1Akmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155749
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 1 and its start codon. RT-PCR and Western blot analysis indicated the near absence of mRNA and the absence of protein respectively. (J:155749)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnh3 Mutation: 42 strains or lines available

References

• Original: J:155749 Miyake A, et al., Disruption of the ether-a-go-go K+ channel gene BEC1/KCNH3 enhances cognitive function. J Neurosci. 2009 Nov 18;29(46):14637-45
• All: 1 reference(s)