Tg(Camk2a-KCNH3)1Akmi
Transgene Detail

Summary

• Symbol: Tg(Camk2a-KCNH3)1Akmi
• Name: transgene insertion 1, Akira Miyake
• MGI ID: MGI:4418368
• Synonyms: OVER
• Transgene: Tg(Camk2a-KCNH3)1Akmi Location: unknown
• Alliance: Tg(Camk2a-KCNH3)1Akmi page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-KCNH3)1Akmi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KCNH3 (23416)

  Kcnh3

  (MGI:1341723)

• Mutation details: The Camk2a promoter from C57BL/6 mice (AJ222796) was used to drive expression of a human KCNH3 cDNA specifically in the forebrain. Western blot analysis demonstrated protein overexpression in the forebrain. Three lines were produced but only this representative line was published. (J:155749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:155749 Miyake A, et al., Disruption of the ether-a-go-go K+ channel gene BEC1/KCNH3 enhances cognitive function. J Neurosci. 2009 Nov 18;29(46):14637-45
• All: 1 reference(s)