Kat6a^tm2.2Avo
Targeted Allele Detail

Summary

• Symbol: Kat6a^tm2.2Avo
• Name: K(lysine) acetyltransferase 6A; targeted mutation 2.2, Anne K Voss
• MGI ID: MGI:4418468
• Synonyms: Moz^-
• Gene: Kat6a Location: Chr8:23349551-23433275 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Kat6a^tm2.2Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155755
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 to 7 were flanked by loxP sites (after removal of an Frt-flanked "Pgk1-neomycinphotransferase" selection cassette). Exons 3 to 7 were deleted upon cre mediated recombination. (J:155755)

Expression

In Mice Carrying this Mutation:	64 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kat6a^tm2.2Avo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat6a Mutation: 69 strains or lines available

References

• Original: J:155755 Voss AK, et al., Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity. Dev Cell. 2009 Nov;17(5):674-86
• All: 7 reference(s)