Ntsr1^tm2Pang
Targeted Allele Detail

Summary

• Symbol: Ntsr1^tm2Pang
• Name: neurotensin receptor 1; targeted mutation 2, Zhen Pang
• MGI ID: MGI:4418470
• Synonyms: NTR1^-
• Gene: Ntsr1 Location: Chr2:180141769-180186772 bp, + strand Genetic Position: Chr2, 103.04 cM, cytoband H1-H4
• Alliance: Ntsr1^tm2Pang page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155994
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon, containing the ATG start codon, was replaced with a floxed neomycin resistance cassette. Absence of mRNA was demonstrated by RT-PCR. (J:155994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntsr1 Mutation: 31 strains or lines available

References

• Original: J:155994 Mechanic JA, et al., Involvement of the neurotensin receptor 1 in the behavioral effects of two neurotensin agonists, NT-2 and NT69L: lack of hypothermic, antinociceptive and antipsychotic actions in receptor knockout mice. Eur Neuropsychopharmacol. 2009 Jul;19(7):466-75
• All: 3 reference(s)