Ehmt2^tm1.1Tara
Targeted Allele Detail

Summary

• Symbol: Ehmt2^tm1.1Tara
• Name: euchromatic histone lysine N-methyltransferase 2; targeted mutation 1.1, Alexander Tarakhovsky
• MGI ID: MGI:4418499
• Synonyms: G9a^f
• Gene: Ehmt2 Location: Chr17:35117445-35133028 bp, + strand Genetic Position: Chr17, 18.45 cM
• Alliance: Ehmt2^tm1.1Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155931
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 23 and 24 were floxed and an FRT-flanked neo cassette inserted into intron 24 via homologous recombination. The selection cassette was then removed by flp mediated recombination. Cre-mediated recombination results in out-of-frame splicing and nonsense mediated decay of the mutant transcript. (J:155931)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehmt2 Mutation: 57 strains or lines available

References

• Original: J:155931 Sampath SC, et al., Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell. 2007 Aug 17;27(4):596-608
• All: 17 reference(s)