Pdcd4^tm1.1Tosc
Targeted Allele Detail

Summary

• Symbol: Pdcd4^tm1.1Tosc
• Name: programmed cell death 4; targeted mutation 1.1, Tobias Schmid
• MGI ID: MGI:4418524
• Synonyms: pdcd4^delta2,3
• Gene: Pdcd4 Location: Chr19:53880662-53918291 bp, + strand Genetic Position: Chr19, 48.73 cM
• Alliance: Pdcd4^tm1.1Tosc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132696
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt flanked neomycin cassette with a 5' attached loxP site was inserted in intron 3. An additional loxP site was inserted in intron 1. Exons 2 and 3 of the resulting allele are thus flanked by loxP sites. Mice were crossed to transgenic mice carrying a beta actin-cre to excise exons 2 and 3. This results in a frameshift mutation creating a stop site at codon 16. The resulting mice retain the frt flanked neomycin resistance cassette. (J:132696)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd4 Mutation: 21 strains or lines available

References

• Original: J:132696 Schmid T, et al., Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion. Cancer Res. 2008 Mar 1;68(5):1254-60
• All: 1 reference(s)