Tg(Krt14-HIF1A*)2Dcbe
Transgene Detail

Summary

• Symbol: Tg(Krt14-HIF1A*)2Dcbe
• Name: transgene insertion 2, David C Beebe
• MGI ID: MGI:4418544
• Synonyms: K14-HIF-1alpha-Pro^402A/564G
• Transgene: Tg(Krt14-HIF1A*)2Dcbe Location: unknown
• Alliance: Tg(Krt14-HIF1A*)2Dcbe page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Krt14-HIF1A*)2Dcbe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HIF1A (3091)

  Hif1a

  (MGI:106918)

• Mutation details: The promoter drives epithelial cell-specific expresison of a human cDNA with nucleotide susbtitutions that lead to amino acid substitutions of alanine and glycine for proline at positions 402 and 564. No line information given. (J:141905)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:141905 Shui YB, et al., HIF-1: an age-dependent regulator of lens cell proliferation. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4961-70
• All: 1 reference(s)