About   Help   FAQ
Ehmt1tm1.2Tara
Targeted Allele Detail
Summary
Symbol: Ehmt1tm1.2Tara
Name: euchromatic histone methyltransferase 1; targeted mutation 1.2, Alexander Tarakhovsky
MGI ID: MGI:4418565
Gene: Ehmt1  Location: Chr2:24680781-24809658 bp, - strand  Genetic Position: Chr2, 16.73 cM
Alliance: Ehmt1tm1.2Tara page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155739
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 23 was floxed and an FRT-flanked neo cassette was inserted into intron 23 via homologous recombination. The selection cassette and exon 23 were removed by flp and cre mediated recombination, respectively. Cre-mediated recombination results in out-of-frame splicing and nonsense mediated decay of the mutant transcript. (J:155739)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ehmt1 Mutation:  91 strains or lines available
References
Original:  J:155739 Schaefer A, et al., Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 2009 Dec 10;64(5):678-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory