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Ehmt1tm1.2Tara
Targeted Allele Detail
Summary
Symbol: Ehmt1tm1.2Tara
Name: euchromatic histone methyltransferase 1; targeted mutation 1.2, Alexander Tarakhovsky
MGI ID: MGI:4418565
Gene: Ehmt1  Location: Chr2:24680781-24809658 bp, - strand  Genetic Position: Chr2, 16.73 cM
Alliance: Ehmt1tm1.2Tara page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155739
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 23 was floxed and an FRT-flanked neo cassette was inserted into intron 23 via homologous recombination. The selection cassette and exon 23 were removed by flp and cre mediated recombination, respectively. Cre-mediated recombination results in out-of-frame splicing and nonsense mediated decay of the mutant transcript. (J:155739)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ehmt1 Mutation:  91 strains or lines available
References
Original:  J:155739 Schaefer A, et al., Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 2009 Dec 10;64(5):678-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory