Tg(Fabp4-Ccl2)BYt
Transgene Detail

Summary

• Symbol: Tg(Fabp4-Ccl2)BYt
• Name: transgene insertion B, Yoshikazu Tamori
• MGI ID: MGI:4418675
• Transgene: Tg(Fabp4-Ccl2)BYt Location: unknown
• Alliance: Tg(Fabp4-Ccl2)BYt page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-Ccl2)BYt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ccl2 (MGI:98259)

• Mutation details: The mouse promoter drives adipocyte-specific expression of the mouse cDNA. Nine lines were created. Line B exhibits a 3.9-fold increase in expression compared with wild-type mice and was selected as the representative line. Line A exhibits a 100-fold increase in expression. (J:110277)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:110277 Kanda H, et al., MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006 Jun;116(6):1494-505
• All: 1 reference(s)