Tardbp^tm1.1Ckjs
Targeted Allele Detail

Summary

• Symbol: Tardbp^tm1.1Ckjs
• Name: TAR DNA binding protein; targeted mutation 1.1, C K James Shen
• MGI ID: MGI:4418700
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^tm1.1Ckjs page

Tardbp^tm1.1Ckjs/Tardbp^tm1.1Ckjs embryos show defective development of the inner cell mass in vitro

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2 and 3 were flanked by lox sites and an FRT flanked neo cassette and a 29 bp deletion for genotyping were inserted in intron 3 via homologous recombination. Cre mediated recombination removed the selection cassette and exons including the translational start site. Protein was undetectable by immunofluorescence after E3.5. (J:155958)

Generation of the Tardbp^tm1Ckjs and Tardbp^tm1.1Ckjs alleles

Disease models

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 68 strains or lines available

References

• Original: J:155958 Wu LS, et al., TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis. Genesis. 2010 Jan;48(1):56-62
• All: 2 reference(s)