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Enpp2tm1Mmas
Targeted Allele Detail
Summary
Symbol: Enpp2tm1Mmas
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2; targeted mutation 1, Masayuki Masu
MGI ID: MGI:4418729
Synonyms: ATX-, Enpp2lacZ
Gene: Enpp2  Location: Chr15:54702297-54816284 bp, - strand  Genetic Position: Chr15, 21.6 cM, cytoband D2
Alliance: Enpp2tm1Mmas page
Small size, absence of embryo turning and angiogenic defects in the yolk sack of Enpp2tm1Mmas/Enpp2tm1Mmas embryos

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156013
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6 and 7 were replaced with an IRES-lacZ and inverted neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of mRNA and protein expression in homozygous embryos and extraembryonic coelomic fluid, respectively. (J:156013)
Generation of the Enpp2tm1Mmas allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Enpp2 Mutation:  79 strains or lines available
References
Original:  J:156013 Koike S, et al., Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac. J Biol Chem. 2009 Nov 27;284(48):33561-70
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory