Enpp2tm1Mmas
Targeted Allele Detail
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Symbol: |
Enpp2tm1Mmas |
Name: |
ectonucleotide pyrophosphatase/phosphodiesterase 2; targeted mutation 1, Masayuki Masu |
MGI ID: |
MGI:4418729 |
Synonyms: |
ATX-, Enpp2lacZ |
Gene: |
Enpp2 Location: Chr15:54702297-54816284 bp, - strand Genetic Position: Chr15, 21.6 cM, cytoband D2
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Alliance: |
Enpp2tm1Mmas page
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Small size, absence of embryo turning and angiogenic defects in the yolk sack of Enpp2tm1Mmas/Enpp2tm1Mmas embryos
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:156013
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 6 and 7 were replaced with an IRES-lacZ and inverted neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of mRNA and protein expression in homozygous embryos and extraembryonic coelomic fluid, respectively.
(J:156013)
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Generation of the Enpp2tm1Mmas allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Enpp2 Mutation: |
79 strains or lines available
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Original: |
J:156013 Koike S, et al., Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac. J Biol Chem. 2009 Nov 27;284(48):33561-70 |
All: |
5 reference(s) |
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