Cttn^tm1.1Okab
Targeted Allele Detail

Summary

• Symbol: Cttn^tm1.1Okab
• Name: cortactin; targeted mutation 1.1, Shigeo Okabe
• MGI ID: MGI:4418948
• Gene: Cttn Location: Chr7:143989468-144024743 bp, - strand Genetic Position: Chr7, 88.84 cM
• Alliance: Cttn^tm1.1Okab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155986
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A single lox site was introduced 0.5-kb downstream of Exon 4. A reporter fusion construct containing a FRT site, splice acceptor (derived from 0.6kb upstream of exon 6), the cDNA from exons 6-18, IRES, b-galactosidase-neo, polyA, FRT site and an additional loxP site were inserted within intron 5 by homologous recombination. (J:155986)

Generation of the Cttn^tm1.1Okab and Cttn^tm1.2Okab alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cttn Mutation: 28 strains or lines available

References

• Original: J:155986 Tanaka S, et al., Generation of cortactin floxed mice and cellular analysis of motility in fibroblasts. Genesis. 2009 Sep;47(9):638-46
• All: 1 reference(s)