Isl1^tm3Sev
Targeted Allele Detail

Summary

• Symbol: Isl1^tm3Sev
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 3, Sylvia Evans
• MGI ID: MGI:4418967
• Synonyms: isl1-nLacZ
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm3Sev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156167
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a loxP-flanked nuclear lacZ (nLacZ) reporter gene, followed by a humanized renilla GFP (hrGFP) sequence and an FRT-flanked neomycin resistance gene, was inserted into a SalI site of the Isl1 locus, replacing a short segment of coding sequence including the endogenous ATG start codon. (J:156167)

Expression

In Mice Carrying this Mutation:

206 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 36 strains or lines available

References

• Original: J:156167 Sun Y, et al., Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007 Apr 1;304(1):286-96
• All: 11 reference(s)