Hcn4^tm1Sev
Targeted Allele Detail

Summary

• Symbol: Hcn4^tm1Sev
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1, Sylvia Evans
• MGI ID: MGI:4418969
• Synonyms: HCN4-H2B-EGFP
• Gene: Hcn4 Location: Chr9:58730695-58770458 bp, + strand Genetic Position: Chr9, 31.8 cM, cytoband C
• Alliance: Hcn4^tm1Sev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156167
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The targeting cassette containing histone 2B fused EGFP (H2B-EGFP) following an FRT-mclNeo gene was introduced by homologous recombination into HCN4 locus just before the translation initiation site. (J:156167)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn4 Mutation: 67 strains or lines available

References

• Original: J:156167 Sun Y, et al., Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007 Apr 1;304(1):286-96
• All: 1 reference(s)