Zmynd10^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Zmynd10^{tm1(KOMP)Wtsi}
• Name: zinc finger, MYND domain containing 10; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419323
• Synonyms: Zmynd10^-
• Gene: Zmynd10 Location: Chr9:107424497-107428518 bp, + strand Genetic Position: Chr9, 58.12 cM
• Alliance: Zmynd10^{tm1(KOMP)Wtsi} page
• IMPC: Zmynd10 gene page

Mutation origin

• Mutant Cell Lines: EPD0408_5_A05, EPD0408_5_A06, EPD0408_5_A07, EPD0408_5_A08, EPD0408_5_B05, EPD0408_5_B06, EPD0408_5_B07, EPD0408_5_C05, EPD0408_5_C06, EPD0408_5_C07, EPD0408_5_D05, EPD0408_5_D08, EPD0408_5_E05, EPD0408_5_E06, EPD0408_5_F05, EPD0408_5_F06, EPD0408_5_F07, EPD0408_5_F08, EPD0408_5_G05, EPD0408_5_G06, EPD0408_5_G07, EPD0408_5_G08, EPD0408_5_H05, EPD0408_5_H07
• Germline Transmission: Earliest citation of germline transmission: J:261915
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3131 starting at position 107424966 and ending at position 107428097 of Chromosome 9 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534, J:261915)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Zmynd10 Mutation: 21 strains or lines available

Notes

Cell line EPD0408_5_D08 was successfully used to make chimeric mice. Germline transmission was accomplished. J:261915

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 3 reference(s)