Blvrb^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Blvrb^{tm1(KOMP)Wtsi}
• Name: biliverdin reductase B; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419545
• Gene: Blvrb Location: Chr7:27147403-27165406 bp, + strand Genetic Position: Chr7, 15.9 cM
• Alliance: Blvrb^{tm1(KOMP)Wtsi} page
• IMPC: Blvrb gene page

Mutation origin

• Mutant Cell Lines: EPD0411_2_A01, EPD0411_2_A02, EPD0411_2_B01, EPD0411_2_C02, EPD0411_2_C04, EPD0411_2_D02, EPD0411_2_D03, EPD0411_2_D04, EPD0411_2_E02, EPD0411_2_E03, EPD0411_2_G03
• Germline Transmission: Earliest citation of germline transmission: J:211773
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3520 starting at position 27158669 and ending at position 27162189 of Chromosome 7 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Blvrb Mutation: 19 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 6 reference(s)