Pde4ctm1(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Pde4ctm1(KOMP)Wtsi |
Name: |
phosphodiesterase 4C, cAMP specific; targeted mutation 1, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:4419834 |
Gene: |
Pde4c Location: Chr8:71176485-71203835 bp, + strand Genetic Position: Chr8, 34.15 cM, cytoband B3-C1
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Alliance: |
Pde4ctm1(KOMP)Wtsi page
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IMPC: |
Pde4c gene page |
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Mutant Cell Lines: |
EPD0375_3_A09, EPD0375_3_A11, EPD0375_3_B10, EPD0375_3_D11, EPD0375_3_E10, EPD0375_3_H09, EPD0375_3_H12 |
Germline Transmission: |
Earliest citation of germline transmission:
J:188991
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 4555 starting at position 71197807 and ending at position 71202362 of Chromosome 8 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site.
(J:148605, J:173534)
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Original: |
J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009; |
All: |
3 reference(s) |
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