Cnpy1^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cnpy1^{tm1(KOMP)Wtsi}
• Name: canopy FGF signaling regulator 1; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419843
• Gene: Cnpy1 Location: Chr5:28405817-28450786 bp, - strand Genetic Position: Chr5, 13.99 cM
• Alliance: Cnpy1^{tm1(KOMP)Wtsi} page
• IMPC: Cnpy1 gene page

Mutation origin

• Mutant Cell Lines: EPD0392_3_A03, EPD0392_3_B03, EPD0392_3_B04, EPD0392_3_D03, EPD0392_3_D04, EPD0392_3_F01, EPD0392_3_F03, EPD0392_3_G02, EPD0392_3_G03
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 2350 starting at position 28411999 and ending at position 28414349 of Chromosome 5 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Cnpy1 Mutation: 22 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 5 reference(s)