Hes7^tm1.1Dihz
Targeted Allele Detail

Summary

• Symbol: Hes7^tm1.1Dihz
• Name: hes family bHLH transcription factor 7; targeted mutation 1.1, David Ish-Horowicz
• MGI ID: MGI:4420236
• Synonyms: Hes7^BAP
• Gene: Hes7 Location: Chr11:69011230-69014881 bp, + strand Genetic Position: Chr11, 42.38 cM
• Alliance: Hes7^tm1.1Dihz page

Truncated tails in Hes7^tm1.1Dihz/Hes7^tm1.1Dihz (BAP/BAP) and Hes7^tm1Kag/Hes7^tm1Kag (Hes7-/-) fetuses

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155378
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A 42 bp insertion encoding a 14 amino acid BAP tag was inserted into the fourth exon 17 amino acids upstream of the C terminus. In addition a floxed neo resistance cassette was inserted and then removed by Cre mediated recombination leaving a loxP site in the third intron. Repressor activity of the resulting tagged protein is impaired making this a hypomorphic allele. Protein expression is increased compared to wild-type controls. (J:155378)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hes7 Mutation: 22 strains or lines available

References

• Original: J:155378 Stauber M, et al., Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis. PLoS One. 2009;4(11):e7996
• All: 1 reference(s)