Tg(Thy1-APPSwe)1Lngn
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSwe)1Lngn
• Name: transgene insertion 1, Lars Nilsson
• MGI ID: MGI:4420244
• Synonyms: tg-APPSwe, TgSwe
• Transgene: Tg(Thy1-APPSwe)1Lngn Location: unknown
• Alliance: Tg(Thy1-APPSwe)1Lngn page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSwe)1Lngn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: A human amyloid beta (A4) precursor protein cDNA sequence (APP695) was altered to include the APP KM670/671NL (Swedish) Familial Alzheimer's Disease (FAD) mutation. The resultant APPSwe construct was then placed downstream of the mouse thymus cell antigen 1, theta [Thy1] promoter (via insertion into the ATG start site in exon 2 of the mouse Thy1 locus in the Thy-1323-cassette). The resulting transgene was microinjected into (C57BL/6xCBA)F1 pronuclear oocytes. Two founder lines were generated and one line displaying 3-fold overexpression of human APP in the brain was analyzed further. (J:105265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105265 Lord A, et al., The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice. Neurobiol Aging. 2006 Jan;27(1):67-77
• All: 11 reference(s)