Tg(Nes-cre/Esr1*)1Kuan
Transgene Detail

Summary

• Symbol: Tg(Nes-cre/Esr1*)1Kuan
• Name: transgene insertion 1, Chia-Yi Kuan
• MGI ID: MGI:4420448
• Synonyms: nestin-CreER, Tg(Nes-cre/ER)1Kuan
• Transgene: Tg(Nes-cre/Esr1*)1Kuan Location: unknown
• Alliance: Tg(Nes-cre/Esr1*)1Kuan page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nes-cre/Esr1*)1Kuan expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Nes (25491)

  Nes	(MGI:101784)

• Mutation details: The transgene construct contains the rat nestin second intron enhancer fused to an hsp68 (Hspa1b) minimal promoter driving a 1.6 kb cre sequence fused to the tamoxifen-inducible mutant estrogen receptor (Esr1*). The linearized construct was microinjected into pronuclei of fertilized C57BL/6 eggs. Three lines of nestin-cre/Esr1* mice were generated. (J:156372)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Alliance rat Nes gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:156372 Burns KA, et al., Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia. Cereb Cortex. 2007 Nov;17(11):2585-92
• All: 14 reference(s)