Tg(tetO-LRRK2*G2019S)E3Cai
Transgene Detail

Summary

• Symbol: Tg(tetO-LRRK2*G2019S)E3Cai
• Name: transgene insertion E3, Huaibin Cai
• MGI ID: MGI:4420755
• Synonyms: G2019S, LRRK2 G2019S, tetO-LRRK2 G2019S
• Transgene: Tg(tetO-LRRK2*G2019S)E3Cai Location: unknown
• Alliance: Tg(tetO-LRRK2*G2019S)E3Cai page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-LRRK2*G2019S)E3Cai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: A transgenic vector was generated encoding the C-terminal hemagglutinin (HA)-tagged human LRRK2*G2019S mutant gene under control of a tetO promoter. The construct was microinjected into C57BL/6J fertilized oocytes, and three independent lines were generated. Founder mice were bred to C57BL/6J mice to establish the E3 line. (J:133490, J:156512)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:156512 Lin X, et al., Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24;64(6):807-27
• All: 4 reference(s)