Ptgs2^tm1.1Wls
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1.1Wls
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1.1, William L Smith
• MGI ID: MGI:4420987
• Synonyms: delta 18 muCox2
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1.1Wls page

Hypertoprhy of glomeruli in Ptgs2^tm1Unc/Ptgs2^tm1Unc mice that is not seen in Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156331
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted Mutations: Insertion, Intragenic deletion Mutation details: Genomic sequence that codes for amino acids 595 through 612 was deleted by mutagenesis. A floxed neo cassette was inserted upstream of the modified exon 10. Cre mediated recombination removed the neo cassette. The predicted protein lacks the last 18 C-terminal amino acids. (J:156331)

Generation of the Ptgs2^tm1.1Wls allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 73 strains or lines available

References

• Original: J:156331 Wada M, et al., Two pathways for cyclooxygenase-2 protein degradation in vivo. J Biol Chem. 2009 Nov 6;284(45):30742-53
• All: 1 reference(s)