Rr2^tm1Hgc
Targeted Allele Detail

Summary

• Symbol: Rr2^tm1Hgc
• Name: regulatory region 2; targeted mutation 1, Edward M Rubin
• MGI ID: MGI:4421031
• Synonyms: uc329^-
• Gene: Rr2 Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Rr2^tm1Hgc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128347
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Ultra-conserved nucleotide sequence 329 (uc329), in an intron of Them7, was replace by a loxP site flanked neomycin selection cassette. The neo cassette was subsequently removed by transient cre expression in ES cells. (J:128347)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr2 Mutation: 0 strains or lines available

References

• Original: J:128347 Ahituv N, et al., Deletion of ultraconserved elements yields viable mice. PLoS Biol. 2007 Sep;5(9):e234
• All: 1 reference(s)