Nacatm1.1Star
Targeted Allele Detail
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Symbol: |
Nacatm1.1Star |
Name: |
nascent polypeptide-associated complex alpha polypeptide; targeted mutation 1.1, Rene St-Arnaud |
MGI ID: |
MGI:4421140 |
Synonyms: |
alphaNACS43A |
Gene: |
Naca Location: Chr10:127871444-127884506 bp, + strand Genetic Position: Chr10, 76.39 cM, cytoband D2-D3
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Alliance: |
Nacatm1.1Star page
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Germline Transmission: |
Earliest citation of germline transmission:
J:156411
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 4 was replaced with a modified exon 4 with a T to G mutation that results in an amino acid of alanine for serine at position 43 (S43A). A floxed neo cassette used for ES cell selection was removed by cre mediated recombination. In vitro, the mutation prevents phosphorylation at position 43 and subsequently reduce translocation into the nucleus.
(J:156411)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Naca Mutation: |
71 strains or lines available
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Original: |
J:156411 Meury T, et al., Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo. Mol Cell Biol. 2010 Jan;30(1):43-53 |
All: |
2 reference(s) |
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