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Nacatm1.1Star
Targeted Allele Detail
Summary
Symbol: Nacatm1.1Star
Name: nascent polypeptide-associated complex alpha polypeptide; targeted mutation 1.1, Rene St-Arnaud
MGI ID: MGI:4421140
Synonyms: alphaNACS43A
Gene: Naca  Location: Chr10:127871444-127884506 bp, + strand  Genetic Position: Chr10, 76.39 cM, cytoband D2-D3
Alliance: Nacatm1.1Star page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156411
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 4 was replaced with a modified exon 4 with a T to G mutation that results in an amino acid of alanine for serine at position 43 (S43A). A floxed neo cassette used for ES cell selection was removed by cre mediated recombination. In vitro, the mutation prevents phosphorylation at position 43 and subsequently reduce translocation into the nucleus. (J:156411)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Naca Mutation:  71 strains or lines available
References
Original:  J:156411 Meury T, et al., Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo. Mol Cell Biol. 2010 Jan;30(1):43-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory