Atf7^tm1Sis
Targeted Allele Detail

Summary

• Symbol: Atf7^tm1Sis
• Name: activating transcription factor 7; targeted mutation 1, Shunsuke Ishii
• MGI ID: MGI:4421144
• Gene: Atf7 Location: Chr15:102434381-102533899 bp, - strand Genetic Position: Chr15, 57.66 cM, cytoband F3
• Alliance: Atf7^tm1Sis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156409
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10, which encodes the DNA-binding domain containing the fourth and fifth leucines of the leucine zipper struture, was replaced with a neo cassette. The absence of full-length protein expression and production of a fragment was confirmed by western blot analysis on brain extracts. (J:156409)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atf7 Mutation: 61 strains or lines available

References

• Original: J:156409 Maekawa T, et al., Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. EMBO J. 2010 Jan 6;29(1):196-208
• All: 8 reference(s)