Zfpm1^tm1.1Geab
Targeted Allele Detail

Summary

• Symbol: Zfpm1^tm1.1Geab
• Name: zinc finger protein, multitype 1; targeted mutation 1.1, Gerd A Blobel
• MGI ID: MGI:4421151
• Synonyms: Fog1^ki, Fog^ki, Zfpm1^ki
• Gene: Zfpm1 Location: Chr8:123008880-123063990 bp, + strand Genetic Position: Chr8, 70.86 cM, cytoband E1
• Alliance: Zfpm1^tm1.1Geab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156393
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with one in which amino acids within the NuRD interacting sequence were altered (RRK to GGA), and a frt flanked neo cassette was inserted. Flp mediated recombination removed the neo cassette. Western blot analysis confirmed normal protein expression levels. (J:156393)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfpm1 Mutation: 33 strains or lines available

References

• Original: J:156393 Miccio A, et al., NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 2010 Jan 20;29(2):442-56
• All: 6 reference(s)