Trpm1^tm1Tfur
Targeted Allele Detail

Summary

• Symbol: Trpm1^tm1Tfur
• Name: transient receptor potential cation channel, subfamily M, member 1; targeted mutation 1, Takahisa Furukawa
• MGI ID: MGI:4421441
• Gene: Trpm1 Location: Chr7:63803583-63919523 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Trpm1^tm1Tfur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156502
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 4-6 were replaced with a neo cassette. Northern blot verified no substantial transcript in retinas from homozygous mice. (J:156502)

Generation of the Trpm1^tm1Tfur allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Trpm1 Mutation: 101 strains or lines available

References

• Original: J:156502 Koike C, et al., TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):332-7
• All: 5 reference(s)