Tg(Ins2-Cebpb)2Maka
Transgene Detail

Summary

• Symbol: Tg(Ins2-Cebpb)2Maka
• Name: transgene insertion 2, Masato Kasuga
• MGI ID: MGI:4421493
• Transgene: Tg(Ins2-Cebpb)2Maka Location: unknown
• Alliance: Tg(Ins2-Cebpb)2Maka page

Reduced beta cell mass in Tg(Ins2-Cebpb)2Maka/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Cebpb)2Maka expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cebpb (MGI:88373)

• Tg(Ins2-Cebpb)2Maka expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The rat promoter was used to drive pancreatic expression of the mouse gene. Two lines were created (lines 1 and 2) with 3- and 10-fold increase in expression, respectively. Line 2 was used as the representative line. (J:156725)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:156725 Matsuda T, et al., Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest. 2010 Jan;120(1):115-26
• All: 2 reference(s)