Tg(Ppp1r2-cre)4127Nkza
Transgene Detail

Summary

• Symbol: Tg(Ppp1r2-cre)4127Nkza
• Name: transgene insertion 4127, Kazu Nakazawa
• MGI ID: MGI:4421503
• Synonyms: Cre #4127, Ppp1r2-cre
• Transgene: Tg(Ppp1r2-cre)4127Nkza Location: unknown
• Alliance: Tg(Ppp1r2-cre)4127Nkza page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Ppp1r2-cre)4127Nkza expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ppp1r2 (MGI:1914099)

• Mutation details: BAC homologous recombination was used to insert cre cDNA (fused with a nuclear localization signal (NLS) sequence) immediately upstream of the initiation codon of the Ppp1r2 gene in BAC RPCI-24-322B4. The cre cDNA was followed by the bovin growth hormone-derived polyadenylation signal. In one clone, a 12-kb deletion introduced around the initial methionine codon of the apolipoprotein D (Apod) coding sequence, located 50 kb upstream of Ppp1r2, was identified. This clone was used to prevent overexpression of Apod in the brain of transgenic mice. (J:156785)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ppp1r2 (mouse) Summary of all recombinase alleles driven by Ppp1r2. Comparative matrix view of recombinase activities Alliance mouse Ppp1r2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:156785 Belforte JE, et al., Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci. 2010 Jan;13(1):76-83
• All: 12 reference(s)