Abl1^tm1Goff
Targeted Allele Detail

Summary

• Symbol: Abl1^tm1Goff
• Name: c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 1, Stephen P Goff
• MGI ID: MGI:4421531
• Synonyms: Abl1^m3
• Gene: Abl1 Location: Chr2:31578388-31694239 bp, + strand Genetic Position: Chr2, 21.86 cM, cytoband B
• Alliance: Abl1^tm1Goff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156743
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A mutated NLS1with 5 amino acid substitutions (Lys to Gly) was introduced into exon 11 and a floxed neo cassette was introduced into intron 10 via homologous recombination. Western blot analysis revealed barely detectable levels of the full length mutant protein and low levels of a fragment consisting of the N terminal half. (J:156743)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abl1 Mutation: 93 strains or lines available

References

• Original: J:156743 Qiu Z, et al., c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1136-41
• All: 1 reference(s)