Foxp1^tm1.1Pwt
Targeted Allele Detail

Summary

• Symbol: Foxp1^tm1.1Pwt
• Name: forkhead box P1; targeted mutation 1.1, Philip W Tucker
• MGI ID: MGI:4421653
• Synonyms: Foxp1^f
• Gene: Foxp1 Location: Chr6:98902299-99499682 bp, - strand Genetic Position: Chr6, 45.74 cM, cytoband E1
• Alliance: Foxp1^tm1.1Pwt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156832
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 11 and an additional loxP site was inserted downstream of exon 12. Flp mediated recombination removed the neo cassette leaving exons 11 and 12 floxed. (J:156832)

Expression

In Mice Carrying this Mutation:

7 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxp1 Mutation: 77 strains or lines available

References

• Original: J:156832 Feng X, et al., Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development. Blood. 2010 Jan 21;115(3):510-8
• All: 38 reference(s)