Meig1^tm1Shpi
Targeted Allele Detail

Summary

• Symbol: Meig1^tm1Shpi
• Name: meiosis expressed gene 1; targeted mutation 1, Shmuel Pietrokovski
• MGI ID: MGI:4421665
• Gene: Meig1 Location: Chr2:3410080-3423685 bp, - strand Genetic Position: Chr2, 1.92 cM
• Alliance: Meig1^tm1Shpi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156715
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on testis extracts. (J:156715)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meig1 Mutation: 14 strains or lines available

References

• Original: J:156715 Salzberg Y, et al., Meig1 deficiency causes a severe defect in mouse spermatogenesis. Dev Biol. 2010 Feb 15;338(2):158-67
• All: 1 reference(s)